Overview
Our research is focused on three different problem areas. First, we would like to understand how alternative splicing affects protein function and how the variety of splice forms arising from individual genes is regulated (or not) under pathological states, especially cancer. Second, we are exploring how mining expression microarray data can yield new insights and hypotheses regarding gene function and, more practically, allow an assessment of the reliability of microarray design and analysis methods. Thirdly, we are interested in developing and testing new methods for presenting genome-scale data sets, focusing currently on visualization techniques for gene structures, genome annotations, and data from DNA arrays.
Collaborations
We are also very interested in working with collaborators in other labs. We enjoy applying our expertise to new questions and problems; collaborations give us a chance to learn new fields, try out new technologies, and explore new directions for research.
If you are interested in starting a collaboration or joining the group, contact Ann Loraine.